Articles
2016
Ågerstrand, Marlene. 2016. In Response: Reporting Recommendations to Ensure Reliability
and Reproducibility of Ecotoxicity studies—A Tripartite Initiative. Environmental Toxicology
and Chemistry 35 (5): 1072–73.
Ågerstrand M, Beronius A. 2015. Weight of Evidence Evaluation and Systematic Review in EU
chemical risk assessment: Foundation is laid but guidance is needed. Environment International.
In Press.
Bengtsson-Palme J, Larsson DGJ. (2016) Concentrations of antibiotics predicted to select for
resistant bacteria: Proposed limits for environmental regulation. Environment International.
86:140-149.
Jansson E, Mattsson A, Goldstone J, Berg C. 2016. Sex-dependent expression of anti-Müllerian hormone (amh) and amh receptor 2 during sex organ differentiation and characterization of Müllerian
duct development in Xenopus tropicalis. General and Comparative Endocrinology, in press.
Jonsson V, Österlund T, Nerman O, Kristiansson, E. Statistical evaluation of methods for identification
of differentially abundant genes in comparative metagenomics. 2016. BMC Genomics 17.
Jutkina J, Rutgersson C, Flach CF, Larsson DGJ. (2016) An assay for determining minimal
concentrations of antibiotics that drive horizontal transfer of resistance. Science of the Total
Environment. 548–549:131–138.
Kase R, Moermond C, Korkaric M, Werner I, Ågerstrand M. Criteria for Reporting and
Evaluating ecotoxicity Data (CRED): Comparison and perception of the Klimisch and CRED
methods for evaluating reliability and relevance of ecotoxicity studies. Accepted for publication
in Environmental Science Europe.
Lundström SV, Östman M, Bengtsson-Palme J, Rutgersson C, Thoudal M, Sircar T, Blanck H,
Eriksson KM, Tysklind M, Flach CF, Larsson DGJ. (2016) Minimal selective concentrations
of tetracycline in complex aquatic bacterial biofilms. Science of the Total Environment. 553:
587-595.
Moermond C, Kase R, Korkaric M, Ågerstrand M. 2015. CRED - Criteria for Reporting and
Evaluating ecotoxicity Data. Environmental Toxicology and Chemistry, In Press.
Säfholm M, Jansson E, Fick J, Berg C. 2016. Molecular and histological endpoints for developmenta
reproductive toxicity in Xenopus tropicalis: Levonorgestrel perturbs anti-Müllerian hormone
and progesterone receptor expression. Comparative Biochemistry and Physiology Part C: Toxicology &
Pharmacology. 181–182: 9–18.
2015
Almroth BC, Gunnarsson LM, Cuklev F, Fick J, Kristiansson E, Larsson DGJ. 2015 Waterborne
beclomethasone diproprionate affects fish while its metabolite beclomethasone is not taken up. Science of the Total Environment 511, 37-46.
Ågerstrand M, Berg C, Björlenius B, Breitholtz M, Brunström B, Fick J, Gunnarsson L, Larsson DGJ, Sumpter JP, Tysklind M, Rudén C. (2015) Improving Environmental Risk Assessment of Human Pharmaceuticals. Environmental Science & Technology
Ågerstrand M, Beronius A. 2015. Weight of Evidence Evaluation and Systematic Review in EU chemical risk assessment: Foundation is laid but guidance is needed. Environment International.
Bengtsson-Palme J, Hartmann M, Eriksson KM, Pal C, Thorell K, Larsson DGJ, Nilsson RH. (2015) Metaxa2 – Improved Identification and Taxonomic Classification of Small and Large Subunit rRNA in Metagenomic Data, Molecular Ecology Resources, Accepted for publication.
Bengtsson-Palme J, Larsson DGJ. (2016) Concentrations of antibiotics predicted to select for resistant bacteria: Proposed limits for environmental regulation. Environment International. 86:140-149.
Bengtsson-Palme J, Angelin M, Huss M, Kjellqvist S, Kristiansson E, Palmgren H, Larsson DGJ, Johansson A. (2015) The human gut microbiome as a transporter of antibiotic resistance genes between continents. Antimicrobial Agents and Chemotherapy.
Bengtsson-Palme J, Larsson DGJ. (2015) Antibiotic resistance genes in the environment: prioritizing risks. Nature Reviews Microbiology. 13, 396.
Boulund F, Sjögren A, Kristiansson E. Tentacle: distributed quantification of genes in metagenomes.
2015. Gigascience 4. doi:10.1186/s13742- 015-0078-1.
Carney Almroth BM, Gunnarsson LM, Cuklev F, Fick J, Kristiansson E, Larsson DGJ. 2015. Waterborne beclomethasone diproprionate affects the physiology of fish while its metabolite beclomethasone is not taken up. Science of the Total Environment 511:37-46.
Flach CF, Johnning A, Nilsson I, Smalla K, Kristiansson E, Larsson DGJ. 2015. Isolation of novel IncA/C and IncN fluoroquinolone resistance plasmids from an antibiotic-polluted lake. Journal of Antimicrobial Chemotherapy. 70(10):2709-2717.
Gao K, Yan P, Tan CL, Luo YH, Sun J, Jönsson ME, Brandt I, Tang YP. Chinese Journal of
Environmental Science (Huan Jing Ke Xue). 2015 Oct;36(10):3878-83. In Chinese.
Gorokhova E, Rivetti C, Furuhagen S, Edlund A, Ek K, Breitholtz, M. 2015. Bacteria-mediated effects of antibiotics on Daphnia nutrition. Environmental Science and Technology 49 (9), 5779–5787.
Jansson E, Mattsson A, Goldstone J, Berg C. Sex dependent ontogenetic expression of anti-Müllerian hormone (amh) and amh receptor 2 and characterization of Müllerian duct development in Xenopus tropicalis. Under revision.
Johnning A, Kristiansson E, Fick J, Weijdegard B, Larsson DGJ. 2015. Resistance mutations in gyrA and parC are common in Escherichia communities of both fluoroquinolone-polluted and uncontaminated aquatic environments. Front. Microbiol.
Johnning A, Kristiansson E, Martin A, Marathe NP, Shouche YS, Johansson A, Larsson DGJ. 2015. Quinolone resistance mutations in the faecal microbiota of Swedish travellers to India. BMC Microbiology. 15:235.
Moermond C, Kase R, Korkaric M, Ågerstrand M. 2015. CRED - Criteria for Reporting and Evaluating ecotoxicity Data. Environmental Toxicology and Chemistry.
Runnalls, T.J., Beresford, N., Kugathas, S., Margiotta-Casaluci, L., Scholze, M., Scott, A.P. and
Sumpter, J.P. 2015. From single chemicals to mixtures - reproductive effects of levonorgestrel
and ethinylestradiol on the fathead minnow. Aquatic Toxicology 169: 152–167.
Säfholm M, Jansson E, Fick J, Berg C. 2015. Mixture Effects of Levonorgestrel and Ethinylestradiol: Estrogenic Biomarkers and Hormone Receptor mRNA Expression during Sexual Programming. In Press Aquatic Toxicology
Säfholm M, Jansson E, Fick J, Berg C. 2015. Molecular and histological endpoints for developmental reproductive toxicity in Xenopus tropicalis: Levonorgestrel perturbs anti-Müllerian hormone and progesterone receptor expression, Comparative Biochemistry and Physiology, Part C. In press.
Säfholm M, Jansson E, Fick J, Berg C. Levonorgestrel up-regulates anti-Müllerian hormone (amh) and progesterone receptors (pgrs) mRNA expression during sex organ differentiation in Xenopus (Silurana) tropicalis. Under revision.
Svensson J, J Fick, I Brandt & B Brunström (2014) Environmental concentrations of an androgenic progestin disrupts the seasonal breeding cycle in male three-spined stickleback (Gasterosteus aculeatus). Aquatic Toxicology 147, 84-91.
Wernersson A-S et al (in total 46 authors). 2015. The European technical report on aquatic effect-based monitoring tools under the water framework directive. Environmental Sciences Europe. 27:7.
Whaley P, Halsall C, Ågerstrand M, Benford D, Aiassa E, Bilotta G, Boyd I, Coggon D, Collins C, Dempsey C, Duarte-Davidson R, Fitzgerald R, Galay Burgos M, Gee D, Hart A, Hoffmann S, Lam J, Lassersson T, Levy L, Lipworth S, Mackenzie Ross S, Martin O, Meads C, Meyer-Baron M, Miller J, Mongelard P, Pease C, Rooney A, Sapiets A, Stewart G, Taylor D, Verloo D. 2015. Implementing systematic review techniques in chemical risk assessments: challenges and opportunities. Environment International.
2014
Bengtsson-Palme J, Flach C-F, Fick J, Kristiansson E, Larsson DGJ. (2014) Shotgun metagenomics reveals a wide array of antibiotic resistance genes and mobile elements in a polluted lake in India. Front. Microbiol. 5:648. doi: 10.3389/fmicb.2014.00648
Beronius A, L Molander, C Rudén, Hanberg A. (2014) “Facilitating the use of non-standard in vivo studies in health risk assessment of chemicals – a proposal to improve evaluation criteria and reporting.” Journal of Applied Toxicology 34(6):607-17
Brodin T, Piovano S, Fick J, Klaminder J, Heynen M, Jonsson M. (2014) Ecosystem effects of pharmaceuticals in aquatic systems – impacts through behavioural modifications Philosophical Transactions B 369 20130580; doi:10.1098/rstb.2013.0580
Davidsson Å, Kjerstadius H, Haghighatafshar S, Fick J, Olsson M, Wachtmeister H, Eriksson E, la Cour Jansen J. (2014) Effect of anaerobic digestion at 35, 55 and 60°C on pharmaceuticals and organic contaminants. Water Science and Technology 69(6), 1282-1288. (Phase I)
Eriksson Wiklund A-K, Adolfsson Erici M, Liewenborg B, Gorokhova E (2014) Sucralose induces biochemical responses in Daphnia magna. PLOS ONE 9(4): e92771
Furuhagen S, Fuchs A, Lundström Belleza E, Breitholtz M, Gorokhova E (2014) Are pharmaceuticals with evolutionary conserved molecular drug targets more potent to cause toxic effects in non-target organisms? PloS One 9(8). Pages: e105028.
Furuhagen S, Liewenborg B, Breitholtz M, Gorokhova E. (2014) Feeding activity and xenobiotics modulate oxidative status in Daphnia magna: implications for ecotoxicological testing. Environmental Science and Technology 48 (21), 12886–12892.
Grabicova K, Lindberg RH, Östman M, Grabic R, Randak T, Larsson DGJ, Fick J. (2014) Tissuespecific bioconcentration of antidepressants in fish exposed to effluent from a municipal sewage treatment plant. Science of the Total Environment 488-489, 46-50.
Graham DW, Collignon P, Davies J, Larsson DGJ, Snape J. 2014. Underappreciated role of regionally poor water quality on globally increasing antibiotic resistance. Environmental Science & Technology, vol 48, 11746−11747. http://doi.org/10.1021/es504206x
Hey G, Vega SR, Fick J, Tysklind M, Ledin A, la Cour Jansen J, Andersen HR. (2014) Removal of pharmaceuticals in WWTP effluents by ozone and hydrogen peroxide. Water SA, 40, 165-174. (Phase I)
Jonsson M, Fick J, Klaminder J, Brodin T. (2014) Antihistamines and aquatic insects: bioaccumulation and impacts on behavior in damselfly larvae (Zygoptera) Science of the Total Environment, 472, 108-111.
Klaminder J, Fick J, Jonsson M, Sundelin A, Brodin T. (2014) The conceptual imperfection of aquatic risk assessment tests: highlighting the need for tests designed to detect therapeutic effects of pharmaceutical contaminants Environmental Research Letters 9; 084003
Kookana RS, Williams M, Boxall AB , Larsson DGJ, Gaw S, Choi K, Yamamoto H, Shashidhar T, Zhu Y-G, Carriquiriborde P. 2014. Potential Ecological Footprints of Active Pharmaceutical Ingredients: An Examination of Risk Factors in Low-, Middle-, and High-income Countries. Philosophical Transactions of the Royal Society B, 369: 20130586. http://dx.doi.org/10.1098/ rstb.2013.0586.
Larsson DGJ. 2014. Pollution from drug manufacturing: review and perspectives. Philosophical Transactions of the Royal Society B, 369: 20130571. http://dx.doi.org/10.1098/rstb.2013.0571
Larsson DGJ. 2014. Antibiotics in the environment. Upsala Journal of Medical Sciences, 119(2), 108-112.
Lindberg RH, Östman M, Olofsson U, Grabic R, Fick J. (2014) Occurrence and behaviour of 105 active pharmaceutical ingredients in sewage waters of a municipal sewer collection system. Water Research 58, 221-229.
Lundström Belleza E, Brinkmann M, Preuss TG Breitholtz M. (2014) Population-level effects in Amphiascus tenuiremis: Contrasting matrix- and individual-based population models. Aquatic Toxicology 157, 207-214.
Molander L, Ågerstrand M, Beronius A, Hanberg A, Rudén C. 2014. “Science in Risk Assessment and Policy (SciRAP): An Online Resource for Evaluating and Reporting In Vivo (Eco) Toxicity Studies.” Human and Ecological Risk Assessment 21 (3):753-762.
Rutgersson C, Fick J, Marathe N, Kristiansson E, Janzon A, Flach CF, Larsson DGJ. (2014) Fluoroquinolones and qnr genes in sediment, water, soil and human fecal flora in an environment polluted by manufacturing discharges Environmental Science & Technology 48, 7825-7832.
Svensson J, Fick J, Brandt I, Brunström B. (2014) Environmental concentrations of an androgenic progestin disrupts the seasonal breeding cycle in male three-spined stickleback (Gasterosteus aculeatus). Aquatic Toxicology, 147, 84-91.
Shanmugam G, Sampath S, Selvaraj KK, Larsson DGJ, Ramaswamy BR. 2014. Non-steroidal anti inflammatory drugs in Indian rivers. Environmental Science and Pollution Research 21:921-931. doi:10.1007/s11356-013-1957-6.
Säfholm M, Jansson E, Ribbenstedt A, Fick J, Berg C. (2014) Risks of hormonally active pharmaceuticals to amphibians: A growing concern regarding progestagens Philosophical Transactions B 369 20130577; doi:10.1098/rstb.2013.0577
2013
Andersen H R, Antoniou M G, Hey G, Rodriguez S, Spiliotopoulou A, Fick J, Tysklind M, la Cour Jansen J. (2013) Required ozone doses for removing pharmaceuticals from wastewater effluents. Accepted for publication in Science of The Total Environment. (From Phase I)
Antoniou MG, Hey G, Vega SR, Spiliotopoulou A, Fick J, Tysklind M, Ledin A, la Cour Jansen J, Andersen HR. (2013) Required ozone doses for removing pharmaceuticals from wastewater effluents. Science of the Total Environment, 456, 42-49. (From phase I)
Beijer K, Gao K, Jönsson M, Larsson DGJ, Brunström B, Brandt I. (2013) Effluent from drug manufacturing affects cytochrome P450 1 regulation and function in fish. Chemosphere 90: 1149–1157.
Berg C., Backström, T, Winberg, S, Lindberg, R, Fick, J, Brandt, I. (2013) Developmental Exposure to Fluoxetine Modulates the Serotonin System in Hypothalamus.PLoS ONE 8(1):e55053.doi:10.1371/journal.pone.0055053
Brodin T, Fick J, Jonsson M, Klaminder J. (2013) Dilute Concentrations of a Psychiatric Drug Alter Behavior of Fish from Natural Populations. Science 339(6121): 814-815.
Davidsson A, Eriksson E, Fick J. (2013) Ozonation and Thermal Pre-Treatment of Municipal Sewage Sludge-Implications for Toxicity and Methane Potential. Journal of Residuals Sciences & Technology 10(2), 85-91. (From Phase I)
Falås P, Longrée P, la Cour Jansen J, Siegrist H, Hollender J, Joss A. (2013) Micropollutant removal by attached and suspended growth in a hybrid biofilm-activated sludge process.Water research 47 (13), 4498-4506. (From Phase I)
Finley RL, Collignon P, Larsson DGJ, McEwen SA, Li X-Z, Gaze WH, Reid-Smith R, Timinouni M, Graham DW, Topp E. (2013) The scourge of antibiotic resistance: the important role of the environment. Clinical Infectious Diseases doi: 10.1093/cid/cit355.
Flach CF, Boulund F, Kristiansson E, Larsson DGJ. 2013. Functional verification of computationally predicted qnr genes. Annals of Clinical Microbiology and Antimicrobials. 12:34 doi:10.1186/1476-0711-12-34.
Gaze WH, Krone SM, Larsson DGJ, Li XZ, Robinson JA, Simonet P, Smalla K, Timinouni M, Topp E, Wellington EM, Wright GD, Zhu YG. (2013) The impact of humans on the evolution and mobilization of the environmental antibiotic resistome. Emerging Infectious Diseases. 19 (7) Article ID: 12-0871. DOI: 10.3201/eid1907.120871.
Johnning A, Moore ERB, Svensson-Stadler L, Shouche YS, Larsson DGJ, Kristiansson E. 2013. The acquired genetic mechanisms of a multi-resistant bacterium isolated from a treatment plant receiving wastewater from antibiotic production. Appl. Environ. Microbiol., 79(23):7256. doi:10.1128/AEM.02141-13.
Khan GA, Berglund B, Khan KM, Lindgren PE, Fick J. (2013) Occurrence and abundance of antibiotics and resistance genes in rivers, canal and near drug formulation facilities − a study in Pakistan. PLoS ONE 8(6): e62712. doi:10.1371/journal.pone.0062712.
Kristiansson E, Österlund T, Gunnarsson G, Arne G, Larsson DGJ, Nerman O. (2013) A novel method for cross-species gene expression analysis. BMC Bioinformatics 14:70.
Marathe NP, Regina VR, Walujkar SA, Charan SS, Moore ERB, Charan SS, Moore ERB, Larsson DGJ, Shouche YS. 2013. A Treatment Plant Receiving Waste Water from Multiple Bulk Drug Manufacturers Is a Reservoir for Highly Multi-Drug Resistant Integron-Bearing Bacteria. PLoS ONE 8(10): e77310. doi:10.1371/journal.pone.0077310
Pruden A, Larsson DGJ, Amézquita A, Collignon P, Brandt KK, Graham DW, Lazorchak JR, Suzuki S, Silley P, Snape JR, Topp E, Zhang T, Zhu Y-G. (2013) Management Options For Reducing The Release Of Antibiotics And Antibiotic Resistance Genes To The Environment. Environmental Health Perspectives. In press
Rutgersson, C., Gunnarsson, L., Fick, J., Kristiansson, E., Larsson, D.G.J. (2013) Oral Exposure to Industrial Effluent with Exceptionally High Levels of Drugs Does Not Indicate Acute Toxic Effects in Rats. Environmental Toxicology and Chemistry 32, 577–584.
Svensson J, Fick J, Brandt I, Brunström B. (2013) The synthetic progestin levonorgestrel is a potent androgen in the three-spined stickleback (Gasterosteus aculeatus). Environmental Science & Technology 47(4): 2043-2051.
2012
Berg C. (2012) An Amphibian Model for Developmental and Reproductive Toxicity. Methods in Molecular Biology 889: 73-83.
Boxall ABA, Rudd MA, Brooks BW, Caldwell DJ, Choi K, Hickmann S, Innes E, Ostapyk K, Staveley JP, Verslycke T, Ankley GT, Beazley KF, Belanger SE, Berninger JP, Carriquiriborde P, Coors A, DeLeo PC, Dyer SD, Gagné F, Giesy JP, Hallstrom L, Karlsson M, Larsson DGJ, Lazorchak JM, Mastrocco F, McLaughlin A, McMaster ME, Meyerhoff RD, Parrott J, Snape JR, Murray-Smith R, Servos MR, Sibley PK, Straub JO, Szabo ND, Topp E, Tetreault GR, Trudeau VL, Van Der Kraak G. (2012) Pharmaceuticals and Personal Care Products in the Environment: What are the Big Questions? Environmental Health Perspectives. Environ Health Perspect 120:1221–1229.
Breitholtz M, Näslund M, Stråe D, Borg H, Grabic R, Fick J. (2012) An evaluation of free water surface wetlands as tertiary sewage water treatment of micro-pollutants. Ecotoxicology and Environmental Safety 78, 63-71.
Cuklev F, Gunnarsson L, Cvijovic M, Kristiansson E, Rutgersson C, Björlenius B, Larsson DGJ. (2012) Global hepatic gene expression in rainbow trout exposed to sewage effluents: A comparison of different sewage treatment technologies. Science of The Total Environment 427–428: 106–114.
Cuklev F, Fick J, Cvijovic M, Kristiansson E, Förlin L, Larsson DGJ. (2012) Does ketoprofen or diclofenac pose the lowest risk to fish? Journal of Hazardous Materials. 229-230:100-106.
Edlund A, Ek K, Breitholtz M, Gorokhova E. (2012) Antibiotic-induced Change of Bacterial Communities Associated with the Copepod Nitocra spinipes. PLOS One 7(3).
Falås P, Andersen HR, Ledin A and Jansen JC. (2012) Impact of solid retention time and nitrification capacity on the ability of activated sludge to remove pharmaceuticals. Environmental Technology 33(7-9): 865-72. (From Phase I)
Falås P, Baillon-Dhumez A, Andersen HR, Ledin A, la Cour Jansen J. (2012) Suspended biofilm carrier and activated sludge removal of acidic pharmaceuticals. Water research 46 (4), 1167-1175. (From Phase I)
Falås P, Andersen HR, Ledin A, Jansen J. (2012) Occurrence and reduction of pharmaceuticals in the water phase at Swedish wastewater treatment plants. Water Science & Technology . 2012, Vol. 66 Issue 4, p783-791. 9p. (From Phase I)
Hey G, Grabic R, Ledin A, la Cour Jansen J, Andersen HR. (2012) Oxidation of pharmaceuticals by chlorine dioxide in biologically treated wastewater. Chemical Engineering Journal 185, 236-242. (From Phase I)
Grabic R, Fick J, Lindberg RH, Fedorova G, Tysklind M. (2012) Multi-residue method for trace level determination of pharmaceuticals in environmental samples using liquid chromatography coupled to triple quadrupole mass spectrometry Talanta 100, 183-195.
Hey G, Ledin A, Jansen JC and Andersen HR. (2012) Removal of pharmaceuticals in biologically treated wastewater by chlorine dioxide or peracetic acid. Environmental Technology 33(7-9): 1041-7. (From Phase I)
Khan GA., Grabic R., Fick J. (2012) Method development and validation of on-line coupling of solid-phase extraction to liquid chromatography-tandem mass spectrometry for the simultaneous determination of anti-infectives and nasal decongestants. Journal of Pharmaceutical and Biomedical Analysis 66, 24-32.
Roos V, Gunnarsson L, Fick J, Larsson DGJ, Rudén C. (2012) Prioritising pharmaceuticals for environmental risk assessment: Towards adequate and feasible first-tier selection. Science of The Total Environment 421-422: 102-110.
Säfholm M, Norder, A, Fick J, Berg, C. (2012) Disrupted Oogenesis in the Frog Xenopus tropicalis After Exposure to Environmental Progestin Concentrations. Biology of Reproduction 86:126, 1-7.
2011
Cuklev F, Kristiansson E, Fick J, Asker N, Förlin L and Larsson DGJ (2011) Diclofenac in fish - blood plasma levels similar to human therapeutic levels affect global hepatic gene expression. Environ Toxicol Chem 30(9): 2126-34.
Gao K, Brandt I, Goldstone JV and Jönsson ME (2011) Cytochrome P450 1A, 1B, and 1C mRNA induction patterns in three-spined stickleback exposed to a transient and a persistent inducer. Comp Biochem Physiol C Toxicol Pharmacol 154: 42-55.
Hansson SO, Molander L and Rudén C (2011) The substitution principle. Regul Toxicol Pharmacol 59: 454-460.
Holmberg A, Fogel J, Albertsson E, Fick J, Brown JN, Paxéus N, Förlin L, Johnsson JI and Larsson DGJ (2011) Does waterborne citalopram affect the aggressive and sexual behaviour of rainbow trout and guppy? J Hazard Mater 187: 596-599.
Hörsing M, Ledin A, Grabic R, Fick J, Tysklind M, Jansen JC and Andersen HR (2011) Determination of sorption of seventy-five pharmaceuticals in sewage sludge. Water Res 45: 4470-4482. (From Phase I)
Jönsson ME, Berg C, Goldstone JV and Stegeman JJ (2011) New CYP1 genes in the frog Xenopus (Silurana) tropicalis: induction patterns and effects of AHR agonists during development. Toxicol Appl Pharmacol 250: 170-183.
Jönsson ME, Gao K, Olsson JA, Goldstone JV and Brandt I (2011) Induction patterns of new CYP1 genes in environmentally exposed rainbow trout. Aquat Toxicol 98: 311-321.
Kristiansson E, Fick J, Janzon A, Grabic R, Rutgersson C, Weijdegård B, Söderström H and Larsson DGJ (2011) Pyrosequencing of Antibiotic-Contaminated River Sediments Reveals High Levels of Resistance and Gene Transfer Elements. PLoS ONE 6: e17038.
Kvarnryd M, Grabic R, Brandt I and Berg C (2011) Early life progestin exposure causes arrested oocyte development, oviductal agenesis and sterility in adult Xenopus tropicalis frogs. Aquat Toxicol 103: 18-24.
Lennquist A, Asker N, Kristiansson E, Brenthel A, Björnsson BT, Kling P, Hultman M, Larsson DGJ and Förlin L (2011) Physiology and mRNA expression in rainbow trout (Oncorhynchus mykiss) after long-term exposure to the new antifoulant medetomidine. Comparative Biochemistry and Physiology, Part C,154(3): 234-41.
Preuss TG, Brinkman M, Lundstrom E, Bengtsson BE and Breitholtz M (2011) An individual-based modeling approach for evaluation of endpoint sensitivity in harpacticoid copepod life cycle tests and optimization of test design. Environ Toxicol Chem 30: 2353-2362.
Ramaswamy BR, Shanmugam G, Velu G, Rengarajan B and Larsson DGJ (2011) GC-MS analysis and ecotoxicological risk assessment of triclosan, carbamazepine and parabens in Indian rivers. J Hazard Mater 186: 1586-1593.
Samuelsson LM, Björlenius B, Förlin L and Larsson DGJ (2011) Reproducible (1)H NMR-Based Metabolomic Responses in Fish Exposed to Different Sewage Effluents in Two Separate Studies. Environ Sci Technol 45: 1703-1710.
Ågerstrand M, Breitholtz M and Rudén C (2011) Comparison of four different methods for reliability evaluation of ecotoxicity data - A case study of non-standard test data used in environmental risk assessments of pharmaceutical substances. Environ Sci Eur 23: 17.
Ågerstrand M, Küster A, Bachmann J, Breitholtz M, Ebert I, Rechenberg B and Rudén C (2011) Reporting and evaluation criteria as means towards a transparent use of ecotoxicity data for environmental risk assessment of pharmaceuticals. Environmental Pollution 159: 2487-2492.
2010
Accinelli C, Sacca ML, Batisson I, Fick J, Mencarelli M and Grabic R (2010) Removal of oseltamivir (Tamiflu) and other selected pharmaceuticals from wastewater using a granular bioplastic formulation entrapping propagules of Phanerochaete chrysosporium. Chemosphere 81: 436-443.
Accinelli C, Saccà ML, Fick J, Mencarelli M, Lindberg R and Olsen B (2010) Dissipation and removal of oseltamivir (Tamiflu) in different aquatic environments. Chemosphere 79: 891-897.
Albertsson E, Larsson DGJ and Förlin L (2010) Induction of hepatic carbonyl reductase/20beta-hydroxysteroid dehydrogenase mRNA in rainbow trout downstream from sewage treatment works--possible roles of aryl hydrocarbon receptor agonists and oxidative stress. Aquat Toxicol 97: 243-249.
Beijer K, Abrahamson A, Brunström B and Brandt I (2010) CYP1A inhibition in fish gill filaments: a novel assay applied on pharmaceuticals and other chemicals. Aquat Toxicol 96: 145-150.
Fick J, Lindberg RH, Tysklind M and Larsson DGJ (2010) Predicted critical environmental concentrations for 500 pharmaceuticals. Regul Toxicol Pharmacol 58: 516-523.
Fick J, Lindberg RH, Parkkonen J, Arvidsson B, Tysklind M and Larsson DGJ (2010) Therapeutic levels of levonorgestrel detected in blood plasma of fish: results from screening rainbow trout exposed to treated sewage effluents. Environ Sci Technol 44: 2661-2666.
Larsson DGJ (2010) Release of active pharmaceutical ingredients from manufacturing sites--need for new management strategies. Integr Environ Assess Manag 6: 184-186.
Lindberg RH, Fick J and Tysklind M (2010) Screening of antimycotics in Swedish sewage treatment plants--waters and sludge. Water Res 44: 649-657.
Lundström E, Adolfsson-Erici M, Alsberg T, Björlenius B, Eklund B, Lavén M and Breitholtz M (2010) Characterization of additional sewage treatment technologies: ecotoxicological effects and levels of selected pharmaceuticals, hormones and endocrine disruptors. Ecotoxicol Environ Saf 73: 1612-1619.
Strömqvist M, Tooke N and Brunström B (2010) DNA methylation levels in the 5' flanking region of the vitellogenin I gene in liver and brain of adult zebrafish (Danio rerio)--sex and tissue differences and effects of 17alpha-ethinylestradiol exposure. Aquat Toxicol 98: 275-281.
Ågerstrand M and Rudén C (2010) Evaluation of the accuracy and consistency of the Swedish environmental classification and information system for pharmaceuticals. Sci Total Environ 408: 2327-2339.
2009
Berg C, Gyllenhammar I and Kvarnryd M (2009) Xenopus tropicalis as a test system for developmental and reproductive toxicity. J Toxicol Environ Health A 72: 219-225.
Fick J, Söderström H, Lindberg RH, Phan C, Tysklind M and Larsson DG (2009) Contamination of surface, ground, and drinking water from pharmaceutical production. Environ Toxicol Chem 28: 2522-2527.
Gunnarsson L, Adolfsson-Erici M, Björlenius B, Rutgersson C, Förlin L and Larsson DG (2009) Comparison of six different sewage treatment processes--reduction of estrogenic substances and effects on gene expression in exposed male fish. Sci Total Environ 407: 5235-5242.
Gunnarsson L, Kristiansson E, Rutgersson C, Sturve J, Fick J, Förlin L and Larsson DG (2009) Pharmaceutical industry effluent diluted 1:500 affects global gene expression, cytochrome P450 1A activity, and plasma phosphate in fish. Environ Toxicol Chem 28: 2639-2647.
Gyllenhammar I, Holm L, Eklund R and Berg C (2009) Reproductive toxicity in Xenopus tropicalis after developmental exposure to environmental concentrations of ethynylestradiol. Aquat Toxicol 91: 171-178.
Gyllenhammar I, Eriksson H, Söderqvist A, Lindberg RH, Fick J and Berg C (2009) Clotrimazole exposure modulates aromatase activity in gonads and brain during gonadal differentiation in Xenopus tropicalis frogs. Aquat Toxicol 91: 102-109.
Larsson DGJ and Fick J (2009) Transparency throughout the production chain--a way to reduce pollution from the manufacturing of pharmaceuticals? Regul Toxicol Pharmacol 53: 161-163.
Lundström E, Björlenius B, Brinkmann M, Hollert H, Persson JO and Breitholtz M (2009) Comparison of six sewage effluents treated with different treatment technologies--population level responses in the harpacticoid copepod Nitocra spinipes. Aquat Toxicol 96: 298-307.
Molander L, Ågerstrand M and Rudén C (2009) WikiPharma - a freely available, easily accessible, interactive and comprehensive database for environmental effect data for pharmaceuticals. Regul Toxicol Pharmacol 55: 367-371.
Saccà ML, Accinelli C, Fick J, Lindberg R and Olsen B (2009) Environmental fate of the antiviral drug Tamiflu in two aquatic ecosystems. Chemosphere 75: 28-33.
Söderström H, Lindberg RH and Fick J (2009) Strategies for monitoring the emerging polar organic contaminants in water with emphasis on integrative passive sampling. J Chromatogr A 1216: 623-630.
Söderström H, Järhult JD, Olsen B, Lindberg RH, Tanaka H and Fick J (2009) Detection of the antiviral drug oseltamivir in aquatic environments. PLoS One 4: e6064.
Ågerstrand M, Wester M and Rudén C (2009) The Swedish Environmental Classification and Information System for Pharmaceuticals--an empirical investigation of the motivations, intentions and expectations underlying its development and implementation. Environ Int 35: 778-786.
2008
Gunnarsson L, Jauhiainen A, Kristiansson E, Nerman O and Larsson DG (2008) Evolutionary conservation of human drug targets in organisms used for environmental risk assessments. Environ Sci Technol 42: 5807-5813.
Nordberg A, Rudén C and Hansson SO (2008) Towards more efficient testing strategies--analyzing the efficiency of toxicity data requirements in relation to the criteria for classification and labelling. Regul Toxicol Pharmacol 50: 412-419.
Samuelsson LM and Larsson DGJ (2008) Contributions from metabolomics to fish research. Mol Biosyst 4: 974-979.