Endocrine Disruption in AmphibiansDevelopmental Effects of Ethynylestradiol and Clotrimazole on the Reproductive System
Irina Gyllenhammar at the Uppsala University has in her doctoral thesis investigated how the pharmaceuticals ethinylestradiol and clotrimazole (a fungicide used in eg. schampoo) affect the reproductive system in frogs. The findings indicates that low, environmentally relevant concentrations of etinylestradiol has an effect and cause lowered fertility and sex change in frogs.
Amphibian populations are declining world-wide and one of the suggested reasons is environ- mental pollutants. Studies of long-term effects on the reproductive system in frogs following larval exposure to environmental pollutants are scarce. It is therefore important to develop methods to study developmental reproductive toxicity in amphibians. In this thesis the usefulness of Xenopus tropicalis (the West African clawed frog) as a model species for a test system was investigated. Effects on the reproductive system after larval exposure to the pharmaceuticals ethynylestradiol (EE2) and clotrimazole were evaluated.Click here to read more. |
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